Disulfide bond & free sulfhydryl groups analysis

Disulfide bridges, also called disulfide bonds, and free sulfhydryl groups are essential for biopharmaceutical products. The number and position of disulfide bridges are required for obtaining the correctly folded structure and biological function of the proteins. Thus disulfide bridges are crucial for quality control in biopharmaceuticals and the ICH Q6B Guidelines requires the accurate information of the number and position of disulfide bridges.

APTBIO has established a highly sensitive LC-MS/MS platform that can analyze the number and/or position of disulfide bridges present or to detect mismatched or scrambled disulfide bridge formation.

APTBIO can also determine the number of disulfide bonds and free sulfhydryl groups as well as the position and ratio of disulfide bond linkage in the biological pharmaceutical products. 


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